Mr Warmbier’s family announced the news via an emotional statment from Ohio.
Warmbier, who was imprisoned in North Korea for 17 months, was returned home in a coma less than a week ago.
He died in a Cincinnati hospital, his family said in a statement on Monday.
Otto was returned from North Korea in a coma, not able to understand language and had severe brain damage.
Authorities in Kim Jong-Un’s North said he had fallen ill with food poisoning and taken a sleeping tablet – which doctors in the US find no evidence of.
“Unfortunately, the awful torturous mistreatment our son received at the hands of the North Koreans ensured that no other outcome was possible beyond the sad one we experienced today,” the family said in a statement.
The student was accused by North Korea of being involved in a plot to overthrow the Jong-Un regime.
In fact, he stole a sign in a hotel in the secretive nation while on a trip.